Hey Joseph. The first trick to enjoying PhotoLab is to use it on the biggest screen possible. PhotoLab is 4K aware so if you acquire a 4K monitor (some decent sRGB ones don’t cost much more than PhotoLab these days), you can have the interface at normal size (HDPI/Retina in Mac talk: say 2560 virtual pixels wide instead of the 3820 real pixels) with the image showing real pixels.
The second key is much easier: switch often between zoom to fit (command-0) and 100% (command-1). I also use PhotoLab on a MBP 17" and there I’m switching back and forth very often.
The third key is not to try to do image evaluation/culling in PhotoLab. It’s much too slow switching between images and creating previews for this kind of fast-paced work. I use FastRawViewer (all of $15) for this. Others here use other software like iMatch.
What PhotoLab is really good at it helping a photographer create very high quality images from his or her RAW files, with lens correction, excellent sharpening and contrast tools and best of class noise reduction. If you’re a Canon shooter like me, you’ll enjoy two more stops of usable ISO (my limits: I can happily shoot to 6400 or 12800 with PhotoLab on the front end where 3200 is the outer limit with other software).
Unless you are someone who only shoots digital like film (rolls of 24), bringing all of your images into PhotoLab will be frustrating. I do all my pre-selection in FastRawViewer from an event (hundreds of images), move something like 36 selects into a folder and point PhotoLab at that folder. While processing I’ll throw away another ten or twelve and end up with 24 to 30 images prepped for publication.